A meta-analysis report, published this week in the Archives of Internal Medicine, suggests that consuming coffee reduces the risk of developing type 2 Diabetes. The data is based on 18 studies between 1966 and July of this year.
The findings indicate that for every additional cup of coffee consumed daily, there was an associated 5% to 10% decrease in excess risk of developing diabetes. There was a 25 % reduction in risk when consuming three to four cups of coffee per day over drinking less than three. Similar results were also suggested based on 6 studies on the consumption of decaffeinated coffee and 7 studies on the consumption of tea.
According to researcher, Dr. Rachel Huxley of the George Institute for International Health in Sydney, Australia, and her colleagues - "If such beneficial effects were observed in interventional trials to be real, the implications for the millions of individuals who have diabetes, or who are at future risk of developing it, would be substantial,"
Dr Huxley went on to say - "For example, the identification of the active components of these beverages would open up new therapeutic pathways for the primary prevention of diabetes mellitus. It could also be envisaged that we will advise our patients most at risk for diabetes mellitus to increase their consumption of tea and coffee in addition to increasing their levels of physical activity and weight loss."
Conclusions of the report did however recognize that the individual studies researched were small, and as such, may contain "small study bias", which overestimate the “true magnitude of the association”.
SOURCE
Showing posts with label Diabetes Studies. Show all posts
Showing posts with label Diabetes Studies. Show all posts
Sunday, December 20, 2009
Tuesday, October 20, 2009
India leads the world in the looming epidemic of diabetes
MONTREAL: India leads the world in the looming epidemic of diabetes, the 20th annual World Diabetes Congress of the International Diabetic
Federation (IDF) was told here on Monday.
In its annual report, the IDF said India currently has the highest number of 50.8 million people suffering from diabetes, followed by China with 43.2 million and the US with 26.8 million. The report projected 58.7 million diabetes cases in India by 2010 - almost 7 per cent of its adult population.
By 2030, over 8.4 per cent of the Indian adult population will suffer from diabetes, thanks to the increasing life expectancy and urbanisation, the report said.
Warning Indian policy makers, the report said, "Evidence suggests that in more affluent parts of the country, the rural prevalence is higher than in less affluent rural areas, indicating that increasing economic growth will raise diabetes prevalence in India even more than these possibly conservative estimates have indicated.''
The rampaging diabetes will impose a huge economic burden on India and other countries, it added. Apart from losing billions in lost productivity, the report said, India will also be spending $2.8 billion annually on diabetes control measures by 2010.
There are estimated to be 285 million diabetes cases worldwide, accounting for seven per cent of the world's population.
Diabetes, along with cardiovascular disease, cancer and chronic respiratory diseases, accounts for 60 per cent ff all deaths worldwide.
"Diabetes imposes a large economic burden on the individual, national healthcare system and economy. Healthcare expenditures on diabetes are expected to account for 11.6 per cent of the total healthcare expenditure in the world in 2010,'' the report said.
"Estimated global healthcare expenditures to treat and prevent diabetes and its complications are expected to total at least $376 billion in 2010.''
Addressing the congress, Martin Silink, outgoing president of the International Diabetic Federation, said the epidemic of diabetes will increase from 7 million new cases a year in 2007 to 10 million new cases this year.
The epidemic is getting out of control, said incoming IDF president Jean-Claude Mbanya. He said if the trend continues unchecked, there will be 435 million people with diabetes worldwide by 2030.
More than 12,000 delegates and 400 speakers from around the world are attending the congress.
This article is from economictimes.indiatimes.com
Federation (IDF) was told here on Monday.
In its annual report, the IDF said India currently has the highest number of 50.8 million people suffering from diabetes, followed by China with 43.2 million and the US with 26.8 million. The report projected 58.7 million diabetes cases in India by 2010 - almost 7 per cent of its adult population.
By 2030, over 8.4 per cent of the Indian adult population will suffer from diabetes, thanks to the increasing life expectancy and urbanisation, the report said.
Warning Indian policy makers, the report said, "Evidence suggests that in more affluent parts of the country, the rural prevalence is higher than in less affluent rural areas, indicating that increasing economic growth will raise diabetes prevalence in India even more than these possibly conservative estimates have indicated.''
The rampaging diabetes will impose a huge economic burden on India and other countries, it added. Apart from losing billions in lost productivity, the report said, India will also be spending $2.8 billion annually on diabetes control measures by 2010.
There are estimated to be 285 million diabetes cases worldwide, accounting for seven per cent of the world's population.
Diabetes, along with cardiovascular disease, cancer and chronic respiratory diseases, accounts for 60 per cent ff all deaths worldwide.
"Diabetes imposes a large economic burden on the individual, national healthcare system and economy. Healthcare expenditures on diabetes are expected to account for 11.6 per cent of the total healthcare expenditure in the world in 2010,'' the report said.
"Estimated global healthcare expenditures to treat and prevent diabetes and its complications are expected to total at least $376 billion in 2010.''
Addressing the congress, Martin Silink, outgoing president of the International Diabetic Federation, said the epidemic of diabetes will increase from 7 million new cases a year in 2007 to 10 million new cases this year.
The epidemic is getting out of control, said incoming IDF president Jean-Claude Mbanya. He said if the trend continues unchecked, there will be 435 million people with diabetes worldwide by 2030.
More than 12,000 delegates and 400 speakers from around the world are attending the congress.
This article is from economictimes.indiatimes.com
Wednesday, September 9, 2009
Molecular Mechanism Underlying A Form Of Diabetes Revealed
By investigating a rare and severe form of diabetes in children, University of Iowa researchers have discovered a new molecular mechanism that regulates specialized pancreatic cells and insulin secretion. The mechanism involves a protein called ankyrin, which UI researchers previously linked to potentially fatal human heart arrhythmias.
The findings, which appear this week in the Early Edition of the Proceedings of the National Academy of Sciences, may help identify new molecular targets for treating both rare and common forms of diabetes and hyperinsulinemia.
The Centers for Disease Control and Prevention estimates that 23.6 million people have diabetes in the United States. The condition doubles the risk of death and includes complications such as heart disease, stroke, eye and kidney problems, and peripheral vascular disease.
The University of Iowa team, working with researchers at Washington University in St. Louis, used animal and cellular models to focus on a gene mutation linked with permanent neonatal diabetes mellitus. Children with this genetic form of diabetes have symptoms by age 6 months and require lifelong dependence on insulin to maintain proper glucose levels.
The team discovered that the specific human gene mutation disrupts the ability of the protein ankyrin to regulate a key protein complex known as the KATP channel.
"We have known for some time that human mutations in the KATP channel complex may cause diabetes or hyperinsulinemia," said Faith Kline, Ph.D., the study's lead author and postdoctoral fellow in internal medicine in the University of Iowa Carver College of Medicine. "Now we know something about how this specific KATP channel mutation results in disease.
"The KATP channel essentially functions as a gatekeeper for insulin secretion by pancreatic beta cells. Without proper regulation by this gatekeeper, the pancreatic beta cells are unable to efficiently regulate insulin secretion."
In a healthy individual, pancreatic beta cells respond to changes in blood glucose levels by secreting the appropriate amount of insulin. Beta cell dysfunction may result in abnormal blood glucose regulation and severe diabetes.
"A key finding in this study was identifying the ankyrin protein in the pancreatic beta cell, which is a type of excitable cell. Ankyrins also play critical roles for ion channel regulation in other excitable cells, such as neurons and heart cells called cardiomyocytes," said the paper's senior author, Peter Mohler, Ph.D., University of Iowa associate professor of internal medicine and a Pew Scholar.
Specifically, the team found that the gene mutation prevents most KATP channels from binding with ankyrin, which typically acts as a cellular chaperone. This failure prevents the KATP channels from reaching their normal destination in the cell membrane.
"Ankyrin proteins are like cellular taxi-cabs that carry passenger channels to the cell membrane. In the case of this KATP gene mutation, the ankyrin and channels cannot interact properly, and so the channels basically 'miss their ride' and do not get to the desired location," Mohler said.
The team also found that the few mutant KATP channels that do reach the pancreatic cell membrane do not respond to alterations in cellular metabolism. As a result, the pancreatic beta cells do not release insulin appropriately.
"This is another exciting example of how understanding the basis of rare disease has provided unexpected and fascinating insight into the molecular pathways that govern human physiology," Mohler said.
The Washington University members of the research team were Harley Kurata, Ph.D., and Colin Nichols, Ph.D. Other University of Iowa members of the team included Mark E. Anderson, M.D., Ph.D., Thomas J. Hund, Ph.D., Shane R. Cunha, Ph.D., Patrick Wright, and Olha Koval, Ph.D.
Source:
Becky Soglin
University of Iowa
From medicalnewstoday.com
The findings, which appear this week in the Early Edition of the Proceedings of the National Academy of Sciences, may help identify new molecular targets for treating both rare and common forms of diabetes and hyperinsulinemia.
The Centers for Disease Control and Prevention estimates that 23.6 million people have diabetes in the United States. The condition doubles the risk of death and includes complications such as heart disease, stroke, eye and kidney problems, and peripheral vascular disease.
The University of Iowa team, working with researchers at Washington University in St. Louis, used animal and cellular models to focus on a gene mutation linked with permanent neonatal diabetes mellitus. Children with this genetic form of diabetes have symptoms by age 6 months and require lifelong dependence on insulin to maintain proper glucose levels.
The team discovered that the specific human gene mutation disrupts the ability of the protein ankyrin to regulate a key protein complex known as the KATP channel.
"We have known for some time that human mutations in the KATP channel complex may cause diabetes or hyperinsulinemia," said Faith Kline, Ph.D., the study's lead author and postdoctoral fellow in internal medicine in the University of Iowa Carver College of Medicine. "Now we know something about how this specific KATP channel mutation results in disease.
"The KATP channel essentially functions as a gatekeeper for insulin secretion by pancreatic beta cells. Without proper regulation by this gatekeeper, the pancreatic beta cells are unable to efficiently regulate insulin secretion."
In a healthy individual, pancreatic beta cells respond to changes in blood glucose levels by secreting the appropriate amount of insulin. Beta cell dysfunction may result in abnormal blood glucose regulation and severe diabetes.
"A key finding in this study was identifying the ankyrin protein in the pancreatic beta cell, which is a type of excitable cell. Ankyrins also play critical roles for ion channel regulation in other excitable cells, such as neurons and heart cells called cardiomyocytes," said the paper's senior author, Peter Mohler, Ph.D., University of Iowa associate professor of internal medicine and a Pew Scholar.
Specifically, the team found that the gene mutation prevents most KATP channels from binding with ankyrin, which typically acts as a cellular chaperone. This failure prevents the KATP channels from reaching their normal destination in the cell membrane.
"Ankyrin proteins are like cellular taxi-cabs that carry passenger channels to the cell membrane. In the case of this KATP gene mutation, the ankyrin and channels cannot interact properly, and so the channels basically 'miss their ride' and do not get to the desired location," Mohler said.
The team also found that the few mutant KATP channels that do reach the pancreatic cell membrane do not respond to alterations in cellular metabolism. As a result, the pancreatic beta cells do not release insulin appropriately.
"This is another exciting example of how understanding the basis of rare disease has provided unexpected and fascinating insight into the molecular pathways that govern human physiology," Mohler said.
The Washington University members of the research team were Harley Kurata, Ph.D., and Colin Nichols, Ph.D. Other University of Iowa members of the team included Mark E. Anderson, M.D., Ph.D., Thomas J. Hund, Ph.D., Shane R. Cunha, Ph.D., Patrick Wright, and Olha Koval, Ph.D.
Source:
Becky Soglin
University of Iowa
From medicalnewstoday.com
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